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Do probiotics work for IBS?

Published: June 21, 2025 by Anna-Kaisa Manolova

While incompletely understood, the gut microbiota seems to play an important role in IBS. This, even though an IBS-specific gut microbial signature has not been found. In other words, you can’t tell by looking at someone’s gut microbe test results that they have IBS, but it seems clear that some kind of imbalance in the composition of gut microbes is often present in IBS.

For this reason, impacting the gut microbiota through probiotics has been a hot research topic recent years. 

wooden doll holding blue wax intestines with probiotic pills on the ground in front of it

What are probiotics and are they helpful or IBS?

Probiotics are live micro-organisms that have a health promoting effect on us. Lots of research has been done on IBS and probiotics, yet the studies have been very different from each other, which makes it difficult to compare these studies and make firm conclusions and recommendations. This is why national IBS guidelines are usually quite vague about their recommendations. The American College of Gastroenterology doesn’t recommend them at all at this point, while other national guidelines are more neutral – they say probiotics may help but it’s not clear which probiotic is best for which symptom.

Many probiotic products certainly claim to ease IBS symptoms by improving the microbial balance in the large intestine. On top of this, I know of many cases in which simply starting a probiotic made symptoms nearly disappear.

So, are probiotics a silver bullet for IBS? The truth is, It’s not clear. In my experience, they could help some people, but not all. It seems to be a highly individual matter that depends on many factors and at the moment there’s no way of knowing in advance who might benefit and who might not. 

gut bacteria or microbiota on blue background

Thinking about trying probiotics to ease IBS symptoms?

Here are a few points to be aware of:

Probiotics for IBS? What’s the conclusion?

Should you try probiotics? To me, probiotics could be helpful for IBS, but there are still many unknowns about them. They may help some, but it seems to me that there are other therapies that are probably more useful to invest in first, such as calming the gut-brain axis, the interaction problem between the gut and the brain. Methods that do this calm your nervous system and reduce stress, and as a bonus, they support gut microbes, too. 

Need tips? Here’s an idea, or give me a call and we can chat about your options. 

PS. Are you struggling with bloating? If yes, you might benefit from my free ebook “Why the Balloon Belly”, download it here.

References

Hillestad EMR, van der Meeren A, Nagaraja BH, Bjørsvik BR, Haleem N, Benitez-Paez A, Sanz Y, Hausken T, Lied GA, Lundervold A, Berentsen B. Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome. World J Gastroenterol. 2022 Jan 28;28(4):412-431. doi: 10.3748/wjg.v28.i4.412. PMID: 35125827; PMCID: PMC8790555.

Merenstein D, Pot B, Leyer G, Ouwehand AC, Preidis GA, Elkins CA, Hill C, Lewis ZT, Shane AL, Zmora N, Petrova MI, Collado MC, Morelli L, Montoya GA, Szajewska H, Tancredi DJ, Sanders ME. Emerging issues in probiotic safety: 2023 perspectives. Gut Microbes. 2023 Jan-Dec;15(1):2185034. doi: 10.1080/19490976.2023.2185034. PMID: 36919522; PMCID: PMC10026873.

Satish Kumar L, Pugalenthi LS, Ahmad M, Reddy S, Barkhane Z, Elmadi J. Probiotics in Irritable Bowel Syndrome: A Review of Their Therapeutic Role. Cureus. 2022 Apr 18;14(4):e24240. doi: 10.7759/cureus.24240. PMID: 35602835; PMCID: PMC9116469.

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